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Isabel Leatherwood works on upper body strength at Angela’s Fitness for Women. Leatherwood works out three or four times weekly, and doesn’t think a pill could be an adequate substitute for staying in shape.
Betty Smith /


Experts: No magic pill will replace exercise

By BETTY SMITH
Press special writer

He said frequently diet pills are touted as letting people achieve the desired results by doing little else but taking them. Some of these plans have been approved by the Food and Drug Administration, some haven’t.

There also are a number of diet programs that sell portion-controlled foods. Giese said these low-calorie meals can be effective as long as a person follows the program and doesn’t eat outside foods. But when they start taking lunch hours out, eating Sunday dinner at grandma’s, or otherwise straying from the regimen, the weight usually comes back.

“To make your muscle tissue better, you have to do certain things,” he said.

One is to increase your efficiency at burning calories. Fit people tend to burn more calories than unfit people.

Giese cited a program that measured the effects of exercise on people, doing biopsies of their muscle tissue before and after.

“After 16 weeks you could see very striking changes in muscle tone,” he said.

Participants showed an increase in mitochondrial structure and density.

That’s good news for people who like to eat as well as exercise.

“Fit people can eat incredible amounts of calories, many more than unfit people, but their muscle capacity, their engine, is very fit,” Giese said. “Eating is a habit. You can overeat and you can undereat.”

He doubts similar results can be achieved without exercise.

“A pill doesn’t change your muscle tissue,” he said.

The key is the SDH enzyme, which increases in the muscles of people who exercise regularly.

“Fit people have huge quantities of SDH and other people don’t,” Giese said.

The no-exercise drug is called AICAR. Previous experiments suggested it might protect against gaining weight on a high-fat diet, which might be useful for treating obesity, Evans said. But it would have to be taken for a long time and its safety in people would have to be assured.

Evans, who told the AP he has no financial interest in either drug in the study, said he had doubted the experiment would work.



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