GIANTS 27, PACKERS 13
At East Rutherford, N.J., defensive end Jason Pierre-Paul scored on a spectacular, leaping 24-yard fourth-quarter interception return and the resurgent Giants won their fourth game in a row by beating slumping and injured-riddled Green Bay.
Eli Manning threw a 26-yard touchdown pass to Rueben Randle and Brandon Jacobs added a 1-yard run as the host Giants (4-6) handed the Packers (5-5) their third straight loss, their longest skid since a five-game losing streak near the end of 2008.
Two of the three losses have come with quarterback Aaron Rodgers sidelined with a broken left collarbone.
While Scott Tolzien played well at times in his first NFL start, the Giants intercepted him three times.
CARDINALS 27, JAGUARS 14
At Jacksonville, Fla., Carson Palmer threw for 419 yards and two scores and did not throw an interception for the first time all season.
Michael Floyd had a career-high 193 yards receiving, including a 91-yard touchdown on a catch-and-run as the Cardinals (6-4) won their third straight game.
The Jaguars (1-9) at least scored a touchdown at home for the first time this season. On fourth-and-2 from the 38 on the opening drive, Chad Henne found tight end Danny Noble behind the defense for a 62-yard score. It was Noble's first NFL reception.
BILLS 37, JETS 14
At Orchard Park, N.Y., Jairus Byrd had two interceptions in leading a Buffalo defense that forced four turnovers. Kyle Williams had two sacks and forced a fumble, and Da'Norris Searcy returned Geno Smith's third interception 32 yards for a touchdown. Buffalo (4-7) snapped a three-game skid.
Buffalo's EJ Manuel won Round 2 of the AFC East showdown of rookie quarterbacks by finishing 20 of 28 for 245 yards and two scores.
Smith struggled in blustery conditions, finishing 8 of 23 for 103 yards four turnovers — including a lost fumble — before being yanked in favor of Matt Simms after three quarters.
The visiting Jets (5-5) became the NFL's first team to alternate wins and losses through the first 10 games of the season.